Hemmerling et al. [94] adopted a construction-based design approach to obtain a novel course of indazole ether based molecular scaffolds and evaluated their glucocorticoid receptor (GR) modulate routines. The results indicated that several illustrations shown efficacy inside a cellular transrepression assay at picomolar concentrations.We use cookie
Mechanistic reports exposed compound forty eight induced S-period cell cycle arrest and apoptosis in CCRF-CEM cells. The structure–activity marriage (SAR) analysis indicated that a 5,six-dimethoxy moiety along with a 2-ethyl ester group on the indole scaffold were important for fantastic antiproliferative potency, highlighting the opportunity of
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